Clinical Evidence

2021

Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label non-randomized clinical trial

Phytother Res.2021; 1-8. DOI: 10.1002/ptr.7004

To evaluate the efficacy of nano-curcumin oral formulation in mild-moderate COVID-19 patients.


Effects of curcuminoids on inflammatory and oxidative stress biomarkers and clinical outcomes in critically ill patients: A randomized double-blind placebo-controlled trial

Phytother Res.2021; 1-11. DOI: 10.1002/ptr.7179

To evaluate the efficacy of nano-curcumin oral formulation in mild-moderate COVID-19 patients.


Effect of curcumin on severity of functional dyspepsia: A triple blinded clinical trial

Advances in experimental medicine and biology. 2021; 1308

To evaluate the effect of curcumin supplementation on improving functional dyspepsia.

2020

Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: A randomized double-blind placebo-controlled trial

Phytother Res.2020; 1-9. DOI: 10.1002/ptr.6749

To evaluate the effects of curcuminoids supplementation on serum concentrations of leptin and adiponectin… 


Effects of curcuminoids on inflammatory status in patients with nonalcoholic fatty liver disease: A randomized controlled trial

Complement Ther Med. 2020; 49: 102322.
https://doi.org/10.1016/j.ctim.2020.102322

To assess the effect of curcuminoids supplementation on inflammatory cytokines in patients with NAFLD… 


Use of curcumin in multiple myeloma patient’s intolerant of steroid therapy

Clin Case Rep.2020; 00: 1-8. DOI: 10.1002/ccr3.2735

To assess the effect of curcuminoids supplementation on inflammatory cytokines in patients with NAFLD… 


Antioxidant properties of curcumin and its impact on arteriovenous fistula maturation in end-stage kidney disease patient with diabetes mellitus type 2

Int J Res Pharm Sci.2020; 11(4): 7624-7629.
DOI: https://doi.org/10.26452/ijrps.v11i4.4107

To assess the effect of curcumin and acetylsalicylic acid on total antioxidant capacity (TAC) in end-stage kidney disease patient with diabetes mellitus type 2 (ESRD) patients… 


The effects of curcumin and acetylsalicylic acid to arteriovenous fistula maturation in end-stage renal disease patients with diabetes mellitus

Spec Care Dentist.2019; 39(2):166-172. DOI: 10.1111/scd.12358

To compare the effect of curcumin, acetylsalicylic acid, and placebo on arteriovenous fistula … 


Curcumin help arteriovenous fistula maturation

Am J Med Case Rep.2020; 8 (10): 365-366. DOI: 10.12691/ajmcr-8-10-12

To assess the effect of curcumin on arteriovenous fistula maturation in diabetic end stage renal disease patients… 

2019

The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial

Nutr Neurosci.. 2015; 65 (11): 567-73. DOI: 10.1055/s-0034-1389986

To evaluate the combined effects of nano-curcumin and CoQ10 supplementation on migraine symptoms and quality of life in migraine patients.


Pharmacokinetics of liposomal curcumin (Lipocurc™) infusion: effect of co-medication in cancer patients and comparison with healthy individuals

Cancer Chemother Pharmacol. 2019;83(2):265–275.
doi:10.1007/s00280-018-3730-5

To study the effect of co-medication (Curcumin and THC with other medications) on the plasma levels… 


Exploratory Study of Curcumin isolated from Turmeric Curcuma longa, the Putative Histone Deacetylase Inhibitor, as added-on strategy to antipsychotics in treating negative symptoms and Neuro-cognitive deficits in Schizophrenia

Adv Res J Multidisciplinary Discov 2019; 40(2): 6-15

To evaluate the potential therapeutic benefit of curcumin against schizophrenia through epigenetic modification… 


Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial

J Nutr.159 (7): 1133-1139. DOI: 10.1093/jn/nxz029

FOLFOX is a chemotherapy regimen for treatment of colorectal cancer, made up of the drugs FOL– Folinic acid (leucovorin), F – Fluorouracil (5-FU), OX – Oxaliplatin… 


Pharmacokinetics, Pharmacodynamics, and PKPD Modeling of Curcumin in Regulating Antioxidant and Epigenetic Gene Expression in Healthy Human Volunteers

Mol Pharm.2019; 16(5): 1881-1889.
DOI: 10.1021/acs.molpharmaceut.8b01246

To describe the acute pharmacokinetics and pharmacodynamics (PK/PD) of curcumin in normal, healthy human volunteers… 


Oral administration of nanomicelle curcumin in the prevention of radiotherapy-induced mucositis in head and neck cancers

Spec Care Dentist.2019; 39(2):166-172. DOI: 10.1111/scd.12358

To evaluate the effect of curcumin in the form of nano-micelle on oral mucositis in head and neck cancer patients receiving radiotherapy… 


The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial

Avicenna J Phytomed.2019;9(1):1-9

To investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina… 


Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial

J Cell Biochem.2019 Sep;120(9):15989-96

Nonalcoholic fatty liver disease (NAFLD) is a most common liver disease condition that is prevalently seen in one out… 

2018

Safety and efficacy of nanocurcumin as add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: A pilot randomized clinical trial

Neurotherapeutics.. 2018; 15 (2): 430-438

To assess the safety and efficacy of nanocurcumin in adults with amyotrophic lateral sclerosis.


A phase II study of curcumin and vitamin D in previously untreated patients with early stage chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)

Blood 2018; 132 (1): 1875

To evaluate the effect of curcumin and vitamin D in early stage chronic lymphocytic leukemia or small lymphocytic lymphoma.


Effects of Curcuminoids Plus Piperine on Glycemic, Hepatic and Inflammatory Biomarkers in Patients with Type 2 Diabetes Mellitus: A Randomized Double-Blind Placebo-Controlled Trial

Drug Res (Stuttg).2018; 68 (7) 403-409. DOI: 10.1055/s-0044-101752

To evaluate the impact of curcuminoids plus piperine administration on glycemic, hepatic and inflammatory biomarkers in type 2 diabetes (T2D) patients… 


Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study

J Evid Based Integr Med.2018; 23:1-8. DOI: 10.1177/2515690X18790725

To evaluate the effect of curcumin and turmeric on the gut microbiota of healthy human subjects… 

2017

Curcumin and piperine supplementation and recovery following exercise-induced muscle damage: a randomized controlled trial

J Sports Sci Med.2017;16(1):147–153. PMID: 28344463

This study aimed to analyze the effects of oral consumption of curcumin and piperine in combination with the recovery kinetics after exercise-induced muscle damage… 


Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial

Inflammopharmacology.2017;25(1):25-31.
DOI: 10.1007/s10787-016-0301-4

To assess the effects of supplementation with curcuminoids, which are natural polyphenolics from turmeric, on oxidative indices in diabetic individuals… 


Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

Inflammopharmacology.2017;25(1):25-31.
DOI: 10.1007/s10787-016-0301-4

To enumerate the effect of curcuminoids on serum lipids in human diabetic subjects… 


Randomized Pharmacokinetic Crossover Study Comparing 2 Curcumin Preparations in Plasma and Rectal Tissue of Healthy Human Volunteers

Inflammopharmacology.2017;25(1):25-31.
DOI: 10.1007/s10787-016-0301-4

To evaluate the pharmacokinetic parameters of phosphatidylcholine curcumin preparations… 


Long-term stabilisation of myeloma with curcumin

BMJ Case Reports.2017; doi:10.1136/bcr-2016-218148

To study the curcumin efficacy as an adjuvant in stage 3 myeloma subject… 


Translating curcumin into clinical practice for treatment of metastatic colorectal cancer: the CUFOX trial. Doctoral (PhD) Thesis. University of Leicester, UK. Degree Awarded date: April 26, 2017. Iwuji, COO

To investigate the safety and feasibility of administering curcumin with standard oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer… 


Phase I dose-escalation trial of intravaginal curcumin in women for cervical dysplasia

Open Access J Clin Trials.2017; 9: 1–10

To assess the safety, tolerability, and pharmacokinetics of intravaginal curcumin in healthy women… 


Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus

Curr Clin Pharmacol.2017;12(4):253-258

Adipokines such as adiponectin and leptin are known to show anti-inflammatory action along with anti-hyperglycemic actions… 


Curcuminoids modify lipid profile in type 2 diabetes mellitus: A randomized controlled trial

Complement Ther Med.2017 Aug;33:1-5.

People with type 2 diabetes mellitus (T2DM) are known to be at greater risk of cardiovascular diseases such as atherosclerosis… 


Curcumin and Lung Cancer: the Role of microRNAs

Curr Pharm Des. 2017;23:1–5

To briefly describe the action of curcumin in regulating the miRNA involved in lung cancer… 

2016

Evaluation of the efficacy of curcumin in the treatment of oral lichen planus: A randomized controlled trial

J Clin Diagn Res. 2016; 10 (5): ZC134–ZC137.
DOI: 10.7860/JCDR/2016/16338.7870

To evaluate the efficacy of curcumin in oral lichen planus.


Effect of NiLitis® SR on knee pain in Japanese adults: A double-blind, randomized, placebo-controlled study

International Journal of Innovative Research in Medical Science 2016 ; 1 (6): 285-293.
https://doi.org/10.23958/ijirms/vol01-i06/08

To assess the effect of NiLitis® SR on knee pain in Japanese adults.


The new combination docetaxel, prednisone and curcumin in patients with castration-resistant prostate cancer: a pilot phase II study


Oncology.2016;90(2):69–78. doi:10.1159/000441148

The phase II study was the extension of the previous phase I trial, aiming to study the efficacy and safety of docetaxel/curcumin combination in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (CRPC)… 


Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial


Inflammopharmacology.2016. DOI: 10.1007/s10787-016-0301-4

To investigate the antioxidant properties of bioavailability-improved preparations of curcuminoids in diabetic patients… 


Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial

Drug Res. 2016;66:1–5

To evaluate the efficacy of Curcumin C3 Complex® as adjunctive therapy on the eradication of H. pylori infection and severity of dyspepsia in patients with PU… 


Effects of curcumin on serum cytokine concentrations in subjects with metabolic syndrome: A post-hoc analysis of a randomized controlled trial

Biomed Pharmacother. 2016;82:578–82

To evaluate the effect of supplementation with Curcumin C3 Complex® on concentration of serum cytokines in subjects with MetS… 


Effects of supplementation with Curcumin on serum adipokine concentrations: A randomized controlled trial

Nutrition.2016, DOI: 10.1016/j.nut.2016.03.018

To evaluate changes in serum levels of adiponectin and leptin, and the ratio of these two adipokines, following Curcumin supplementation in patients with MetS…. 


Effects of Curcuminoids-Piperine Combination on Systemic Oxidative Stress, Clinical Symptoms and Quality of Life in Subjects with Chronic Pulmonary Complications Due to Sulfur Mustard: A Randomized Controlled Trial

J Diet Suppl. 2016; 13(1):93-105

Exposure to Sulphur Mustard (SM) during Iraq-Iran war (1980-88), not only affected the skin but also caused chronic complications in the respiratory system of civilian and army personnel… 


Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial

J Diet Suppl. 2016; 13(2):209-20

To evaluate the efficacy of Curcumin supplementation in reducing the oxidative stress by measuring the levels of serum concentration of important biomarkers in patients with knee OA…

2015

Short-term curcuminoid supplementation for chronic pulmonary complications due to sulfur mustard intoxication: Positive results of a randomized double-blind placebo-controlled trial

Drug Res (Stuttg). 2015; 65 (11): 567-73. DOI: 10.1055/s-0034-1389986

To evaluate the clinical effects of curcuminoids supplementation on markers of pulmonary function and systemic inflammation in sulfur mustard intoxicated subjects.


Enhanced systemic bioavailability of curcumin through transmucosal administration of a novel microgranular formulation

Anticancer Res. 2015;35(12):6411–6418. PMID: 26637850

To determine the bioavailability, efficacy, and safety of microgranular curcumin formulation, with transmucosal absorption property, in cancer subjects and healthy volunteers… 


The Effect of Curcumin on some of Traditional and Non-traditional Cardiovascular Risk Factors: A Pilot Randomized, Double-blind, Placebo-controlled Trial

Iran J Pharm Res. 2015; 14(2):479-486

To investigate the efficacy of curcumin in subjects with coronary artery disease (CAD) by evaluating lipid profile, blood glucose level and inflammatory markers… 


Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy

Cancer Lett. 2015; 364(2):135-41

To assess the safety, tolerability and feasibility of administering oral Curcumin during standard FOLFOX chemotherapy for palliation of colorectal liver metastases… 


Combining curcumin (C3 complex, Sabinsa) with standard care FOLFOX chemotherapy in patients with inoperable colorectal cancer (CUFOX): study protocol for a randomised control trial

Trials 2015. DOI: 10.1186/s13063-015-0641-1

This randomized, controlled clinical study will be evaluating the effects of CUFOX (Curcumin and FOLFOX) regimen on the colon cancer subjects… 


An investigation of the effects of Curcumin on anxiety and depression in obese individuals: A randomized controlled trial

Chin J Integr Med. 2015; 21(5):332-38

To investigate the antioxidant and anti-inflammatory efficacy of Curcumin on the frequency of symptoms of anxiety and depression in obese individuals… 


Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

Clin Nutr. 2015. DOI: 10.1016/j.clnu.2014.12.019

This study was conducted to understand the effect of curcuminoids on systemic oxidative stress and inflammation by measuring superoxide dismutase activity… 


Effect of curcuminoids on oxidative stress:A systematic review and meta-analysis of randomized controlled trials

J Funct Foods. 2015, DOI: 10.1016/j.jff.2015.01.005

To perform meta-analysis on Curcumin formulations to assess the effect of Curcuminoids supplementation on oxidative stress in health as well as in disease conditions…


Investigation of the Efficacy of Adjunctive Therapy with Bioavailability-Boosted Curcuminoids in Major Depressive Disorder

Phytother Res. 2015; 29(1):17-21

Major depressive disorder (MDD) is the most common psychological disorder. The symptoms include irritable mood, disrupted sleep, loss of motivation, decreased concentrating power and even suicidal intentions…


Impact of Supplementation with Curcuminoids on Systemic Inflammation in Patients with Knee Osteoarthritis: Findings from a Randomized Double-Blind Placebo-Controlled Trial

Drug Res. 2015; 65(10):521-25

Osteoarthritis (OA) is a degenerative joint disease associated with inflammation. Inflammatory response activates chondrocytes and synoviocytes to produce matrix degrading enzymes… 

2014


Short-term Curcuminoid Supplementation for Chronic Pulmonary Complications due to Sulfur Mustard Intoxication: Positive Results of a Randomized Double-blind Placebo-controlled Trial

Drug Res. 2014. DOI: http://dx.doi.org/10.1055/s-0034-1389986

To investigate effects of Curcuminoids supplementation on markers of pulmonary function and systemic inflammation in SM-intoxicated subjects… 


Lipid-modifying effects of adjunctive therapy with curcuminoids–Piperine combination in patients with metabolic syndrome: Results of a randomized controlled trial

Complement Ther Med. 2014; 22(5):851-57

To investigate the effects of bioavailability-enhanced Curcuminoids in patients with metabolic syndrome on serum lipid concentration, as an adjunctive to standard of care… 


Are Curcuminoids Effective C-Reactive Protein-Lowering Agents in Clinical Practice? Evidence from a Meta-Analysis

Phytother Res. 2014; 28(5):633-42

To perform a meta-analysis of clinical trials for investigating the effect of Curcuminoids supplementation on serum CRP concentrations… 


Curcuminoid Treatment for Knee Osteoarthritis: A Randomized Double-Blind Placebo-Controlled Trial

Phytother Res. 2014; 28(11):1625-31

Osteoarthritis (OA) is the most common disease of joints in adults which leads to stiffness of joints, pain and limitation in joint movement. Treatment of OA is challenging due to inefficacy and long… 


Investigation of the effects of Curcumin on serum cytokines in obese individuals: A randomized controlled trial

Sci World J. 2014. DOI: 10.1155/2014/898361

Obesity is a global health problem and its predisposing effects are atherosclerosis, hypertension, type 2 diabetes, and dyslipidemia… 

2013

Topical Curcumin for the Prevention of Oral Mucositis in Pediatric Patients: Case series

Altern Ther Health Med. 2013; 19(3):21-24

Oral mucositis (OM), a common consequence of chemotherapy, is caused by inflammation and necrosis of oral mucosa. It has been reported in 40 to 80% of pediatric oncology patients… 


Effect of a herbal extract containing Curcumin and Piperine on midazolam, flurbiprofen and paracetamol (acetaminophen) pharmacokinetics in healthy volunteers

Br J Clin Pharmacol. 2013; 75(2):450-62

Today Curcuminoids have been evaluated for management for several health conditions including Alzheimer’s dementia, cancer and other inflammatory conditions… 


Effects of Supplementation with Curcuminoids on Dyslipidemia in Obese Patients: A Randomized Crossover Trial

Phytother Res. 2013; 27(3):374-9

Obesity is the major health problem and risk factor for diabetes, dyslipidemia, hyperlipidemia and osteoarthritis… 


Curcuminoids modulate pro-oxidant antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese Individuals

Phytother Res. 2013; 27(12):1883-8

Oxidative stress is involved in pathogenesis of atherosclerosis, because of its involvement in oxidation of LDL cholesterol… 


Prolonged biologically active colonic tissue levels of Curcumin achieved after oral administration- A clinical pilot study including assessment of patient acceptability

Cancer Prev Res. 2013; 6(2):119-128

In previous studies the pharmacokinetic and pharmacodynamics parameters of Curcumin have been reported but few data is available describing whether methodologies are suitably robust for Curcuminoids… 


Curcumin for radiation dermatitis: a randomized, double blind, placebo controlled clinical trial of thirty breast cancer patients

Radiat Res. 2013; 180(1):34-43

Radiation dermatitis is the common side effect in 95% of patients receiving radiotherapy for sarcoma or various other types of cancer. Skin is susceptible to damage by ionizing radiation because it is a highly proliferative and self-renewing organ… 


Long term use of curcumin in two smoldering multiple myeloma patients

J Hematol Malign.2013;3(1):18-23

To study the long term use of Curcumin in two male patients with plasma cell dyscrasias.. 

2012

Improvement of sulphur mustard-induced chronic pruritus, quality of life and antioxidant status by Curcumin: results of a randomised, double-blind, placebo-controlled trial

Br J Nutr. 2012; 108 (7):1272-9

Sulfur Mustard [Bis (2-chloroethyl) sulphide] or SM has been used as chemical warfare agent for almost 100 years. SM is a compound with potent alkylating, vesicant, blister-forming, cytotoxic, mutagenic and carcinogenic properties… 


A randomized controlled trial on the anti-inflammatory effects of Curcumin in patients with chronic sulphur mustard-induced cutaneous complications

Ann Clin Biochem. 2012; 49(Pt 6):580-88

To investigate the impact of Curcumin on serum inflammatory biomarkers and their association with pruritus severity and QoL…


To assess the efficacy and safety of NILIN™ SR tablets in the management of osteoarthritis of Knee

Int J Pharm Life Sci. 2012; 3(2):1413-23

Osteoarthritis (OA) or degenerative joint disease is one of the oldest and most common types of arthritis, which leads to breakdown of the joint’s cartilage. This results in rubbing of bones against eachother, causing pain and loss of movement… 


High dose Curcuminoids are efficacious in the reduction in symptoms and signs of oral lichen planus

J Am Acad Dermatol. 2012; 66(5):752-60

To evaluate the efficacy, safety and tolerability of Curcuminoids at a dose of 6000 mg/day in patients with OLP… 


Use of Curcuminoids in a cohort of patients with oral lichen planus, an autoimmune disease

Phytomedicine 2012; 19(5);418-423

To summarize long-term open-label use of over the counter (OTC) Curcuminoids i. e. doses,duration and their side effects (including changes in blood count or liver enzymes) in 53 patients with Oral Lichen Planus (OLP) who previously participated in either of the randomized controlled trials of Curcuminoids at UCSF… 


Proof of concept of randomized controlled study of Curcumin C3 Complex as adjunct treatment in Schizophrenia: effects on negative and depressive symptoms

Cultivating Natural Bioactives: International Conference July 9 to 11, 2012

Authors designed a parallel group randomized trial (15 subjects) of schizophrenia with persisted negative symptomsF… 


Oral Curcumin for Alzheimer’s disease: Tolerability and efficacy in a 24 week randomized, double blind, placebo controlled study

Alzheimers Res Ther. 2012; 4(5):43

To generate tolerability and preliminary clinical and biomarker efficacy data on Curcumin C3 complex® in persons with mild to moderate AD… 


Monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and Curcumin: A randomized, double-blind placebocontrolled cross-over 4 g study and an open-label 8 g extension study

Am J Hematol. 2012; 87(5):455-60

Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic plasma cell disorders which can progress to multiple myeloma… 

2011

Oral curcumin supplementation in patients with atopic asthma

Allergy Rhinol (Providence). 2011; 2(2):e51–e53.
doi:10.2500/ar.2011.2.0016

To determine the effect of oral curcumin supplementation on patients with stable, persistent, atopic asthma…


Curcumin and EGCG Suppress Apurinic/Apyrimidinic Endonuclease 1 and Induce Complete Remission in B-cell Non-Hodgkin’s lymphoma Patients

Funct Food Health Dis. 2011; 1(12):525-44

To examine the role of human APE1 in resistance and prognosis in FL patients and to evaluate safety and efficacy of combination of curcumin and epigallocatechin gallate (EGCG) therapy in non-Hodgkin follicular lymphoma patients and their peripheral blood mononuclear cells…


A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer

Cancer Chemother Pharmacol. 2011; 68(1):157-64

To conduct Phase I/II study for determining the safety and feasibility of oral Curcumin in combination with gemcitabine-based chemotherapy in patients with pancreatic cancer… 


Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia

Cancer Prev Res. 2011; 4(3):354-64

To assess effect of oral administration of Curcumin (a major component of Curcumin C3 complex ®) on PGE2 within ACF, 5-HETE, ACF number and proliferation… 

2010

Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress

J Oral Sci. 2010;52(2):251–6

To test the effect of curcumin in patients with leukoplakia, oral submucous fibrosis and lichen planus by measuring serum and salivary levels of MDA, 8-OHdG and Vitamin C, E before and after curcuminoids administration…


Phase I dose escalation trial of docetaxel plus Curcumin in patients with advanced and metastatic breast cancer

Cancer Biol Ther. 2010; 9(1):8-14

To evaluate the role of Curcumin supplementation on breast cancer patients, who were on Docetaxel (100 mg/m2) regimen.In this open-label, Phase I trial, 14 eligible subjects were enrolled who had metastatic… 


Curcumin and Gemcitabine in Patients with Advanced Pancreatic Cancer

Nutr Cancer. 2010; 62(8):1137-41

To evaluate the activity and feasibility of gemcitabine in combination with Curcumin in patients with advanced pancreatic cancer… 

2009

2008

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

Clin Cancer Res. 2008; 14(14):4491-9

To conduct a Phase II study, to determine the biological activity of oral Curcumin in patients with pancreatic cancer… 


Oral Curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial

J Am Acad Dermatol. 2008; 58(4):625-31

To assess the safety and efficacy of oral Curcumin in the treatment of chronic psoriasis vulgaris.. 

2007

Curcumin downregulates NF-κB and related genes in patients with multiple myeloma: results of a Phase I/II study

Blood 2007 110:Abstract1177

To evaluate the clinical safety and biologic effects of Curcumin in multiple myeloma (MM) patients who had asymptomatic, relapsed/refractory, or plateau phase disease…  


A randomized, placebo controlled, double blind clinical trial of Curcuminoids in oral lichen planus

Phytomedicine 2007; 14 (7-8):437-46

To evaluate the efficacy and safety of Curcuminoids as an adjunct to short-course corticosteroids for the treatment of patients with OLP… 

2006

Combination Treatment With Curcumin and Quercetin of Adenomas in Familial Adenomatous Polyposis

Clin Gastroenterol Hepatol. 2006; 4:1035–38

To evaluate the efficacy and toxicity of Curcumin-Quercetin combination to regress intestinal adenomas in subjects suffering from FAP…


Dose escalation of a Curcuminoid formulation

BMC Complement Altern Med. 2006; 6:10

To perform a dose escalation study for determining the maximum tolerated dose, safetyprofile, and resultant serum concentration of a single dose of standardized powdered extract (Curcumin C3 Complex ®) obtained from Alleppey finger turmeric… 

2005

Consumption of the putative chemopreventive agent Curcumin by cancer patients: Assessment of Curcumin levels in the colorectum and their pharmacodynamics consequences

Cancer Epidemiol Biomarkers Prev. 2005; 14(1):120-25

To test the hypothesis that pharmacologically active levels of Curcumin can be achieved in colorectum tissue of humans by oral consumption to effect the levels of M1G and COX-2 proteins…  

2004

Phase I Clinical Trial of Oral Curcumin: Biomarkers of Systemic Activity and Compliance

Clin Cancer Res. 2004; 10(20):6847-54

To analyze toxicity of high doses of Curcumin administered orally to patients with advanced cancer. To investigate the systemic effects of Curcumin consumption…


Detection of Curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration

Br J Cancer. 2004; 90(5):1011-5

To investigate whether oral administration of Curcumin results in concentrations of the agent in normal and malignant liver tissue, which are sufficient to elicit pharmacological activity… 

1998

Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers

Planta Med. 1998; 64(4):353-6

Curcuminoids, despite showing excellent activity in inhibiting the expression of inflammatory cytokines and inhibition of free radicals, due to its low bioavailability and rapid transformation…