Detection of Curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration
Br J Cancer. 2004; 90(5):1011-5
|Curcumin is an effective chemopreventive agent; however it has low systemic bioavailability due to its poor absorption and avid metabolic conjugation and reduction. Despite its low bioavailability following oral administration, it has been earlier reported in rodents that Curcumin exerts biological activity on sites distant from the locus of absorption.|
To investigate whether oral administration of Curcumin results in concentrations of the agent in normal and malignant liver tissue, which are sufficient to elicit pharmacological activity.
12 patients with hepatic metastatic disease from primary colorectal adenocarcinomas were selected. Patients were administered 1, 4, 8 capsules (each capsule containing 450 mg of Curcumin) orally as a daily dose for 1 week prior to surgery. After 1 hour of oral consumption of Curcumin the sample of peripheral blood was collected. After 6-7 h of last dose of Curcumin, hepatic resection was performed and sample of portal blood, bile and further samples of peripheral blood was collected. Levels of Curcumin and its metabolites were measured by HPLC in portal and peripheral blood, bile and liver tissue.
It is the first evidence in humans that oral administration of Curcumin furnishes trace levels (10-8M) of parent compound and its metabolites in the liver tissue and portal circulation.