Translating curcumin into clinical practice for treatment of metastatic colorectal cancer: the CUFOX trial. Doctoral (PhD) Thesis. University of Leicester, UK. Degree Awarded date: April 26, 2017.Iwuji, COO
|Colorectal cancer is also called bowel cancer, colon cancer, or rectal cancer, is any cancerous growth that affects the colon and the rectum. Curcumin is a low molecular weight polyphenol derived from the spice turmeric that inhibits carcinogenesis in vitro and in vivo via multi-targeted mechanisms. A clinical study was established investigating the safety and feasibility of administering curcumin with standard oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.|
To investigate the safety and feasibility of administering curcumin with standard oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.
The study was conducted in two phases
The addition of curcumin to standard FOLFOX chemotherapy up to a dose of 2 grams daily has shown good tolerability, feasibility and no safety concerns across Phase I and Phase IIa of this study.