Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study
J Evid Based Integr Med. 2018; 23:1-8. DOI: 10.1177/2515690X18790725
|Human gut microbiota is a collection of symbiotic microorganisms inhabiting the human intestine. These inhabiting symbiotic microbes play a vital role in nutrition, cognition, immunity and stress response of the host. Their impairment in number and type has been shown to affect the host pathology resulting in various diseases. Thus, managing the microbiota is very crucial in maintaining health. Various prebiotic components and phytoceuticals have been shown to improve the condition of gut microbiome. Curcuminoids have been shown to improve the gut microbiome in the preclinical studies. Insufficient data exist on the effects of curcumin and turmeric on the gut microbiota and such studies in humans are lacking|
To evaluate the effect of curcumin and turmeric on the gut microbiota of healthy human subjects.
Turmeric tablets with extract of piperine (Bioperine®) (n = 6), curcumin with Bioperine® tablets (n = 5), or placebo tablets (n = 3) were provided to healthy human subjects and subsequent changes in the gut microbiota were determined by 16S rDNA sequencing.
Among the responsive participants, both turmeric and curcumin altered the gut microbiota in a highly similar manner, suggesting that curcumin may drive the majority of observed changes observed in turmeric-treated subjects.