Clinical Evidence

The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial
Avicenna J Phytomed.2019;9(1):1-9
Oxidative stress-induced inflammatory reactions play a culprit role in the pathophysiology of unstable angina which precedes acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin possesses both antioxidant and anti-inflammatory potential, hence can have implication in reducing the cardiovascular complications.
Objective:

To investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina.

Methods:

The study was a double-blind randomized clinical trial in forty patients with unstable angina. The selected subjects were randomized into curcumin group (80 mg/day for 5days) and placebo (80 mg/day for 5days). Cardiac function was evaluated by two-dimensional echocardiography devices at baseline (immediately after hospitalization) and 5 days after the onset of the trial. Atrial and ventricular arrhythmias were recorded by Holter monitors.

Results:
  • There were no significant differences between the two groups in atrial and ventricular arrhythmias at the baseline and at the end of the study
  • Echocardiographic parameters were also similar between the groups at baseline and at the end of the study
Conclusion

Nanocurcumin administered at a dose of 80 mg/day for five days had no effect on the incidence of cardiovascular complications in patients with unstable angina.