Clinical Evidence

The synergistic effects of nano-curcumin and coenzyme Q10 supplementation in migraine prophylaxis: A randomized, placebo-controlled, double-blind trial
Nutr Neurosci. 2019. DOI:10.1080/1028415X.2019.1627770
Migraine is a disabling neurovascular disorder characterized by increasing pro-inflammatory cytokines levels and oxidative stress biomarkers. The combine curcumin and coenzyme Q10 (CoQ10) can exert neuroprotective effects through the modulation of inflammation and oxidative stress.

To evaluate the combined effects of nano-curcumin and CoQ10 supplementation on migraine symptoms and quality of life in migraine patients.


The study was a double-blind placebo-controlled trial conducted with 100 episodic migraine subjects. The subjects were divided into four groups: (1) combination of nano-curcumin (80 mg) + CoQ10 (300 mg), (2) nano-curcumin (80 mg), (3) CoQ10 (300 mg) and (4) control for 8 weeks. Frequency, severity, duration of headache attacks, headache diary results and headache disability were assessed based on migraine-specific questionnaires at the baseline and end of the study.

  • The combination of nano-curcumin and CoQ10 supplementation group were showed a significant beneficial effect on the frequency, severity, duration of migraine attacks and headache diary results compared to other groups, also had better scores in
    migraine-specific questionnaires (p<0.001). There were no side effects reported by the participants

A possible synergistic effect of nano-curcumin and CoQ10 on clinical features of migraine.