The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial
Avicenna J Phytomed.2019;9(1):1-9
Oxidative stress-induced inflammatory reactions play a culprit role in the pathophysiology of unstable angina which precedes acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin possesses both antioxidant and anti-inflammatory potential, hence can have implication in reducing the cardiovascular complications.
To investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina.
The study was a double-blind randomized clinical trial in forty patients with unstable angina. The selected subjects were randomized into curcumin group (80 mg/day for 5days) and placebo (80 mg/day for 5days). Cardiac function was evaluated by two-dimensional echocardiography devices at baseline (immediately after hospitalization) and 5 days after the onset of the trial. Atrial and ventricular arrhythmias were recorded by Holter monitors.
- There were no significant differences between the two groups in atrial and ventricular arrhythmias at the baseline and at the end of the study
- Echocardiographic parameters were also similar between the groups at baseline and at the end of the study
Nanocurcumin administered at a dose of 80 mg/day for five days had no effect on the incidence of cardiovascular complications in patients with unstable angina.