Investigation of the effect of short-term supplementation with curcuminoids on circulating small dense low-density lipoprotein concentrations in obese dyslipidemic subjects: a randomized double-blind placebo-controlled cross-over trial.

 

ARYA Atheroscler.2014;10(5):280–286. PMID: 25477987

 

Obesity can lead to various other comorbidities viz., coronary artery disease, hypertension, type 2 diabetes mellitus, respiratory disorders, and dyslipidemia. In dyslipidemia condition there will be altered content and ratio of lipoproteins viz., fasting plasma triglycerides, high LDL cholesterol, low HDL cholesterol, elevated blood glucose, and insulin levels and high blood pressure. Recent advances have identified small dense LDL as metabolic risk factors associated with obesity and dyslipidemia which plays a pivotal role in the induction of comorbidities resulting due to dyslipidemia. Thus, small dense LDL has become one of the markers for dyslipidemia condition and promising target to reduce the comorbidities of dyslipidemia.

 

Objective:

To assess changes in serum small dense LDL concentrations following supplementation with curcuminoids.

 

Methods:

This study was designed as a randomized double-blind placebo-controlled cross-over trial. 30 obese dyslipidemia subjects were assigned to curcuminoids (1 g/day) or placebo for 4 weeks, followed by a 2-week washout and then treatment with the alternate for another 4 weeks. Serum small dense LDL was measured at baseline and weeks 4, 6, and 10 of the trial.

 

Results:

  • Supplementation with curcuminoids (1 g/day) did not cause any significant alteration in serum small dense LDL (P > 0.05) 

 

Conclusion:

Four-week supplementation with curcuminoids was not associated with any significant alteration in circulating small dense LDL concentrations.

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Sabinsa Corporation is a manufacturer, supplier and marketer of herbal extracts, cosmeceuticals, minerals, dietary supplements and specialty fine chemicals for the nutritional, cosmetic, pharmaceutical and food industries.

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Headquarters

Sabinsa Corporation
20 Lake Drive
East Windsor
NJ 08520, USA

Tel: +1.732.777.1111
Fax: +1.732.777.1443
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

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