Effects of supplementation with curcuminoids on serum adipokines in critically ill patients: A randomized double-blind placebo-controlled trial
Phytother Res. 2020; 1-9. DOI: 10.1002/ptr.6749.
Adipokines/ adipocytokines plays a pivotal role in homeostasis of glucose and energy. It also possesses the pro-inflammatory properties which contribute to the progression of inflammation and dysfunction of several organs including kidney, liver, and lung especially in critically ill patient with traumatic brain injury (TBI). This study examined the effects of curcuminoids supplementation on serum levels of adiponectin and leptin in critically ill patients with traumatic brain injury (TBI).
To evaluate the effects of curcuminoids supplementation on serum concentrations of leptin and adiponectin in critically ill patients with traumatic brain injury (TBI).
The study was a double-blind, placebo-controlled, randomized clinical trial, conducted with 62 subjects with TBI, aged 18-65 years. The subjects were randomly allocated to receive either 500 mg/day curcuminoids (co-administered with 5 mg/day piperine) or matched placebo for 7 days. Serum concentrations of leptin and adiponectin were measured at baseline and at the end of trial.
- The study found a significant reduction in serum levels of leptin in both curcuminoids (47.1%) and placebo (22.8%) groups but had no significant effect on adiponectin levels in critically ill patients with TBI (p <0.05).
Supplementation with Curcuminoids significantly reduced the serum levels of leptin but no significant effect on adiponectin levels in critically ill patients with TBI.