Oral nano-curcumin formulation efficacy in management of mild to moderate hospitalized coronavirus disease-19 patients: An open label non-randomized clinical trial

 

   Phytother Res. 2021; 1-8. DOI: 10.1002/ptr.7004.

 

Coronavirus disease 2019 (COVID-19) induced pneumonia became an international concern. Until now, there is no specific approved treatment for COVID-19. Supportive care and oxygen therapy remain as the main steps for patients suffering from COVID-19. Curcumin (derivative of Curcuma longa) is clinically proved for its anti-inflammatory, immunomodulatory potential and also possesses antifibrotic and pulmonoprotective properties. Moreover, it has strong inhibitory effects on NF-κB and several proinflammatory cytokines which can reverse fatal cytokine storm that occurs in COVID-19. Thus, considering these features, raises interest on curcumin for management of mild to moderate COVID-19 patients.

 

Objective:

To evaluate the efficacy of nano-curcumin oral formulation in mild-moderate COVID-19 patients.

 

Method:

The study was an open label non-randomized clinical trial in mild-moderate COVID-19 patients. The subjects were allocated to nano-curcumin (n=21; Sinacurcumin soft gel, contains 40 mg curcuminoids as nanomicelles, two capsules twice a day) or control (n=20) group, supplemented for two weeks.

 

Results:

  • COVID-19 induced symptoms including fever, chillness, tachypnea, myalgia, and cough resolved significantly faster in curcumin group
  • Oxygen saturation (SaO2) was significantly improved from day 2 during the follow-up and lymphocyte count after 7 and 14 days. Further, duration of hospital stay was shorter in curcumin group
  • None of patient experienced deterioration of infection during follow-up period in curcumin group, but it occurred in 40% of control group

 

Conclusion:

Oral nano-curcumin significantly fasten the resolution time of COVID-19 induced symptoms, improves oxygenation and reduces hospital stay in comparison with control group without any adverse effects.

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Sabinsa Corporation is a manufacturer, supplier and marketer of herbal extracts, cosmeceuticals, minerals, dietary supplements and specialty fine chemicals for the nutritional, cosmetic, pharmaceutical and food industries.

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Headquarters

Sabinsa Corporation
20 Lake Drive
East Windsor
NJ 08520, USA

Tel: +1.732.777.1111
Fax: +1.732.777.1443
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

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