Safety and efficacy of nanocurcumin as add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: A pilot randomized clinical trial

 

Neurotherapeutics. 2018; 15 (2): 430-438.

 

Amyotrophic lateral sclerosis (ALS) is a highly progressive and lethal neurodegenerative disorder. Currently, it is considered as incurable and the only approved drug, Riluzole, has a mild effect on survival time. Although etiology is unknown, oxidative stress, mitochondrial dysfunction and neuro-inflammation may be involved. Curcumin is one of the safe and potent components for neurodegenerative diseases. Thus, supplementation of curcumin may improve the motor function and survival in amyotrophic lateral sclerosis

 

Objective:

To assess the safety and efficacy of nanocurcumin in adults with amyotrophic lateral sclerosis.

 

Method:

This was a randomized double-blind, placebo-controlled study in subjects with amyotrophic lateral sclerosis. A total of 54 subjects were randomly allocated to receive either nanocurcumin (80 mg/daily) or placebo for 4 weeks.

 

Results:

  • After 12 months follow-up, events were occurred in one subject (3.7%) in the curcumin group and six subjects (22.2%) in the placebo group. Curcumin supplementation showed better overall survival compared to placebo (p=0.036). No serious adverse events or treatment related deaths were detected.

 

Conclusion:

Curcumin supplementation was found to be safe and might improve the probability of survival as an adjuvant in patients with Amyotrophic lateral sclerosis.

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Sabinsa Corporation is a manufacturer, supplier and marketer of herbal extracts, cosmeceuticals, minerals, dietary supplements and specialty fine chemicals for the nutritional, cosmetic, pharmaceutical and food industries.

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Headquarters

Sabinsa Corporation
20 Lake Drive
East Windsor
NJ 08520, USA

Tel: +1.732.777.1111
Fax: +1.732.777.1443
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

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