Evaluation of the efficacy of curcumin in the treatment of oral lichen planus: A randomized controlled trial

 

J Clin Diagn Res. 2016; 10 (5): ZC134–ZC137. DOI: 10.7860/JCDR/2016/16338.7870.

 

Oral lichen planus (OLP) is a chronic immunological, mucocutaneous disease with a wide range of clinical appearances. The treatment of oral lichen planus is often difficult and disappointing with minimal survival and adverse effects. Curcumin, a low molecular weight flavonoid, possess anti-inflammatory and antioxidant properties has diversified effects in various oral diseases and thus considered to evaluate the effect in oral lichen planus.

 

Objective:

To evaluate the efficacy of curcumin in oral lichen planus.

 

Method:

This was a randomized, double-blind, placebo-controlled study, conducted with 20 Oral lichen planus subjects, randomly allocated to receive either 2000 mg of curcumin supplement daily or placebo for 4 weeks. Further, all subjects were treated with routine mouthwash (Dexamethasone 0.5 mg and suspension Nystatin 100,000 Units). Pain and burning sensation were measured based on the Visual analogue scale, and Thongprasom index.

 

Results:

  • The study showed minimal significant difference between the curcumin supplements and placebo groups (p<0.05)

 

Conclusion:

No detectable effect was observed in Oral lichen planus with low dose curcumin supplement. It is suggested that curcumin can be effective only at higher doses.

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Sabinsa Corporation is a manufacturer, supplier and marketer of herbal extracts, cosmeceuticals, minerals, dietary supplements and specialty fine chemicals for the nutritional, cosmetic, pharmaceutical and food industries.

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Headquarters

Sabinsa Corporation
20 Lake Drive
East Windsor
NJ 08520, USA

Tel: +1.732.777.1111
Fax: +1.732.777.1443
This email address is being protected from spambots. You need JavaScript enabled to view it.

 

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