Investigation of the Absorption Mechanism of Solubilized Curcumin Using Caco-2 Cell Monolayers
J Agric Food Chem. 2011;59(17):9120-26
Poor oral bioavailability of Curcumin hinders multitude health-promoting benefits, and hence, it is very essential to address the issues and enhance its oral bioavailability functional food research. The major limitations for bioavailability of Curcumin are that its water insoluble nature and rapid metabolism. The water solubility of Curcumin is estimated to no more than 11 ng/mL. On the other hand, we have a very limited understanding about the absorption/permeation mechanism of solubilized Curcumin. Caco-2 cell monolayers, in comparison, have been widely used to determine the permeation rate and to examine the permeation mechanisms of bioactive compounds. Caco-2 cell monolayers have been found to predict well the in vivo absorption. |
Objective:
To investigate the absorption of solubilized Curcumin through permeation rate measurements using Caco-2 cell monolayers.
Study Design:
Results:
Discussion:
Overall, Caco-2 cell monolayer model demonstrated that solubilization is the main limiting factor for curcumin absorption and different solubilization agents may affect the permeation rate.