Standardized curcuminoid extract (Curcuma longa l.) decreases gene expression related to inflammation and interacts with associated microRNAs in human umbilical vein endothelial cells (HUVEC)
Food Funct.2012;3:1286–93
Chronic inflammation induced by pathogenic bacterial or viral infection, or other factors play a crucial role in the progression of atherosclerosis. Additionally, other pro-inflammatory mediators like intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1), and endothelial-selection (E-selectin) are known to be involved in causing endothelial dysfunction and tissue injury. Studies have discussed about the role of miRNAs (miRNA-126 and miRNA-146a), regulatory RNAs, during inflammatory process. Studies have demonstrated effects of natural compounds, such as Curcuminoids on inflammation-involved miRNAs in conditions like cancer and apoptosis. However, protective role of Curcuminoids and involvement of miRNAs against chronic inflammation and related endothelial dysfunction is yet to be determined. |
Objective:
To explicate involvement of miRNA-126 and miRNA-146a in the anti-inflammatory effects of Curcuminoids in human umbilical vein endothelial cells (HUVEC).
Study Design:
Results and Discussion:
Conclusion
It was concluded that Curcuminoids exhibit anti-inflammatory effects in HUVEC.