Curcumin possesses tremendous potential to benefit human health; however, its rapid biotransformation has often been cited as a reason for its limited bioavailability. Initial studies carried out to understand its pharmacokinetic properties indicated that following oral administration, Curcumin showed poor absorption resulting in lower blood concentration (traces) and most of it getting excreted in the faeces.
Since Curcumin undergoes rapid biotransformation in the gut and liver, it leads to speculations regarding the bioavailability and metabolic fate of Curcumin. As the research on Curcumin progressed with time, today we have a better insight of Curcumin’s metabolism in the body. Curcumin is metabolized by both conjugation and reduction pathways in the body resulting in formation of several metabolites.
Reference: Majeed M. and Badmaev V. Curcuminoids-Pharmacological Actions Including Pre-Clinical and Clinical Evaluations. In: Curcuminoids: Antioxidant phytonutrients, New Jersey, Nutriscience Publishers Inc., 2003;pp. 32
Potentiating Therapeutic Utility of Curcumin C3 Complex® with BioPerine®
Influence of Piperine on the Pharmacokinetics of Curcumin
Preclinical Study Findings
Clinical Study Findings
This study was path-breaking and first of its kind to demonstrate bio-enhancing potential of piperine in BioPerine®. The evidence showed that piperine is a potent inhibitor for metabolism of certain nutrients/dietary ingredients, which can alter the rate of glucuronidation in gut and liver, thus slowing down the transformation and increasing bioavailability of the nutrients.
Reference: Shoba et al. Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers. Planta Med.1998;64(4):353–56.