Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-ĸB-regulated gene products
Clin Cancer Res. 2008;14(7):2128-36
|Preoperative chemoradiation therapy in rectal cancer has shown that only ~20% of patients achieve complete pathologic responses, mainly because of their resistance to radiation therapy. The reason behind this low response to radiation is not yet understood completely.|
Nuclear factor-ĸB has thought to be closely related with radioresistance in multiple tumors, as suggested by various study outcomes. Hence, novel radiosensitization strategies are needed to enhance this response rate, which may permit selective avoidance of radical surgical resections for a subset of patients.
Curcumin has been found to inhibit NF-ĸB activation as well as down-regulate the expression of NF-ĸB–regulated gene products involved in survival, proliferation, angiogenesis, invasion and metastasis of the tumor. However, it is not clear whether Curcumin sensitizes colorectal tumors to radiation in vivo.
To investigate the effect of Curcumin on the growth of colorectal cancer xenografts in nude mice exposed to radiation.
Results and Discussion:
Antitumor effects of radiation therapy in colorectal cancer were enhanced by Curcumin by inhibiting NF-ĸB and NF-ĸB-regulated gene products