Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer’s disease
|Alzheimer’s disease (AD) is one of the most common forms of dementia, accounting for 50–60% of dementia cases. Generally brain of AD patients is found to be deposited with extracellular amyloid plaques and intracellular neurofibrillary tangles.|
Various compounds derived from the medicinal plants, including turmeric have been known to play a significant role in many diseases, particularly in dementia and Curcumin is the main chemical constituent that imparts such valuable effects. Although Curcuminoid, a key constituent of turmeric, is a mixture of three chemical constituents (Bisdemethoxycurcumin 3–5%, Demethoxycurcumin 15–20% and Curcumin 75–80%), several studies have used Curcumin and Curcuminoid as the same entity probably because Curcumin constitutes the major part, and it is the most extensively studied constituent.
To investigate the effects of curcuminoid mixture and individual constituents on spatial learning and memory in an amyloid-beta (Aβ) peptide-infused rat model of AD and on the expression of PSD-95, synaptophysin and camkIV.
Results and Discussion:
Overall, these findings suggested that at varied time and dose curcuminoid mixture, as well as individual components, showed a beneficial effect on the expression levels of genes involved in synaptic plasticity. Thus, suggesting that potential effects of Curcuminoids involves multiple target sites in spatial memory enhancing and disease modifying in AD.