Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices
|Amyloid plaques, a neurotoxic agent, is a long peptide (Aβ peptide) consisting of 40–42 residues, which is known to cause substantial synaptic loss and neuronal cell degeneration in conditions like Alzheimer’s disease (AD). Although large amount of research has happened to understand the processing and clearance of Aβ peptides, limited success has been achieved in terms of availability of therapeutic options. Hence, newer options are being widely explored in this context.|
Recently, medicinal plant-derived compounds, including turmeric have been explored for their potential advantages in treating AD. It has now been understood that Curcuminoids may interfere with the formation of amyloid plaques and reduce the toxicity of Aβ, because of their multitude activities.
To study the effect of Curcuminoids on Aβ-peptide-induced long-term potentiation (LTP) impairment, in an attempt to provide cellular basis of memory enhancement in AD.
Results and Discussion:
Overall, curcuminoid mixture successfully restored the susceptibility for plastic changes in hippocampal region, which was impaired by Aβ peptide, thus restoring the LTP. Hence, it can be useful in providing pharmacological basis for the medicinal use of Curcuminoids in AD.