Curcumin inhibits skin squamous cell carcinoma tumor growth in vivo
Otolaryngol Head Neck Surg. 2011;145(1): 58-63
|Cutaneous squamous cell carcinoma (SCCa) is one of the most common human malignancies, constitutes approximately 20-25% of non-melanoma skin cancers (NMSC). Over the past several decades, incidence of NMSC has gone up from 4% to 10%. Amongst all skin cancers, SCCa carries the highest rate of mortality, especially adults over age 85 years. Approximately 70% of cases of SCCa of the skin are found in the head and neck.|
Several naturally occurring chemopreventive agents have studied in the recent past to deal with increasing incidence and morbidity of cutaneous SCCa. Curcumin is the one compound that has been studied more recently in this regard. It has been well established that Curcumin acts as a chemopreventive agent in a variety of cancers, and thus its role in the treatment of skin cancer and other skin diseases has also been explored.
To determine whether curcumin has growth-inhibitory effects on cutaneous SCCa using an in vivo murine model.
Results and Discussion:
Curcumin inhibited skin SCCa growth and blocked tumor progression by inhibiting pS6, indicating that it may help prevent skin cancer formation and progression.