Topical curcumin-based cream is equivalent to dietary curcumin in a skin cancer model
J Skin Cancer. 2012;2012:147863
|According to the American Cancer Society, 1–1.3 million cases of nonmelanoma skin cancer (NMSC) are detected annually. Around 20% of all skin cancers is cutaneous skin cell carcinoma (SCC) and 75% of all deaths attributed to skin cancers. Frequency of metastasis is as high as 12.5% for SCC, unlike the more prevalent basal cell carcinoma (BCC), which is non-aggressive.|
It is well known that early cancer detection offers the best window of opportunity for treatment because early stage skin cancer has a high cure rate, whereas advanced stage cutaneous SCC often develops resistance to chemotherapy. Hence, focus on developing novel chemopreventive agents is necessary to delay or prevent cutaneous SCC formation. One such agent is Curcumin, which has in the recent past been examined for its effect in inhibiting skin carcinogenesis.
To determine if topical Curcumin was as efficacious as oral Curcumin in a SCC skin xenograft model, to elucidate the pathways down-regulated by Curcumin as potential biomarkers for future chemopreventive studies and observe the potentially additive effects of topical application and oral dosing.
Results and Discussion:
Curcumin slowed progression of aggressive skin SCC by inhibiting several signaling pathways; hence it can be explored as a chemopreventive and therapeutic agent for skin cancer treatment.