Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer
Eur J Cancer Prev. 2012;21(5):407-12
|In the USA alone 29% of cancer-related deaths are due to lung cancer, which is the leading cause of cancer deaths worldwide as well. Apart from age and obstructive pulmonary disease, cigarette smoking is the major cause of lung cancer in the US.|
Hence, apart from smoking cessation, currently there is an urgent need for safe, effective and novel nutrient-derived substances as chemoprevention agents to modulate lung carcinogenesis. Several researchers have showed that members of the signal transducer and activator of transcription (Stat) family of transcription factors are potential targets in lung cancer and other cancers; particularly targeting Stat3 activation could be an important approach toward the prevention of lung cancers.
Research during the past couple of decades has suggested that Curcumin influences several biochemical and molecular cascades involved in cell cycle regulation, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis and inflammation via multiple molecular targets, and thus substantiating its chemoprevention role.
To study the effect of bioavailable curcuminoid complex on lung carcinogenesis, primarily by inhibiting Stat3 activation and to inform the design of a phase II chemoprevention trial of curcumin in former smokers.
Results and Discussion:
Curcumin effectively inhibited the Stat3 pathway, along with a reduction in cell proliferation, thus can be an effective chemopreventive agent in high risk populations, such as former smokers.