Curcumin induces the differentiation of myeloid-derived suppressor cells and inhibits their interaction with cancer cells and related tumor growth
Cancer Prev Res. 2012;5(2):205-15
|Myeloid-derived suppressor cells (MDSCs) are heterogeneous population of immature myeloid cells, which regulates innate immune responses and suppress T-cell activation in both human and animals. These cells are known to promote tumor growth, angiogenesis, and metastasis. In IL-1β-induced gastric carcinogenesis, one of the initial events is mobilization and activation of MDSCs, which occurs through NF-ĸB pathway, resulting in enhanced IL-6 production in MDSCs. Hence, inhibition of MDSC activation may be an effective approach for gastric cancer prevention.|
Curcumin has been shown to be an antitumor agent, which acts by modulating multiple targets, including suppressing the activity of NF-ĸB and JAK2/Stat3 signaling in tumor cells and immune cells.
To examine the effects of Curcumin on the activation and differentiation of MDSCs, their interaction with human cancer cells, and related tumor growth.
Results and Discussion:
Curcumin significantly inhibited the activation of MDSCs, induced the differentiation of MDSCs and suppressed tumor growth. Hence, antitumerigenic activity of Curcumin may be a promising strategy for cancer prevention and therapy.