Curcumin inhibits UV radiation-induced skin cancer in SKH-1 mice
Otolaryngol Head Neck Surg. 2013;148(5):797-803
|Nearly 1 in 5 Americans get diagnosed for nonmelanoma skin cancer (NMSC), the most common human malignancy, in their lifetime. Though several risk factors have been known to be responsible for the development of NMSC, cumulative effect of chronic exposure to UV radiation remains the most important etiologic factor.|
Though a number of agents have been explored to treat NMSC but clinical trials have been limited and have shown mixed results. Hence, continuous search for novel chemopreventive agents that inhibit formation and progression of NMSC has geared up nowadays.
Curcumin has been considered as a promising anticarcinogenic agent in a variety of malignancies, including gastrointestinal, hematologic, pancreatic, and oral cancer as well in skin carcinogenesis. Recently, topical application of Curcumin has also been investigated to promote prolonged contact and bioavailability at the target site using various skin preparations.
To study if curcumin has inhibitory effects on formation of skin cancers arising de novo from chronic exposure to UV radiation using a similar in vivo murine model.
Results and Discussion:
Curcumin inhibited photocarcinogenesis and delayed tumor multiplicity when treated both orally and topical route, thus suggesting its chemopreventive potential against skin cancer, necessitating future experimentation with human subjects.