Photopreventive effect and mechanism of azd4547 and Curcumin C3 Complex® on UVB-induced epidermal hyperplasia
Cancer Prev Res. 2016;doi: 10.1158/1940-6207
|As indicated by the American Cancer Society, skin cancer is the most common of all type of cancers in the USA due to increased exposure to UV light due to ozone layer depletion. Higher risk prone individuals are those with fair complexion and sun-damaged skin. Squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) together account for non-melanoma skin cancer (NMSC). The SCC is clinically very aggressive and undergoes metastasis, which may result in spreading of cancer around the body. Therefore a “photo-preventive” agent is needed to prevent damage caused due to exposure to UV radiation.|
In a previously published study Curcumin C3 Complex® has already shown positive effect in inhibiting UVB-induced tumor indices and multiplicity. In current study, it has been suggested that this effect of Curcumin C3 Complex® is via the FGFR/mTOR mechanism.
To investigate the efficacy of Curcumin C3 Complex® for protection against acute UVB induced hyper proliferation by FGFR/mTOR signaling pathway.
Results and Discussion:
Curcumin C3 Complex® inhibited both mTOR and FGFR2 signaling, which can be considered as a new therapeutic strategy for advanced cancer with dual pathway dysregulations.