Effects of curcumin on Helicobacter pylori infection
Ann Transl Med2016;4(24):479
|Around the world, more than 50% people are believed to be infected with Helicobacter pylori, a Gram-negative bacterium, which selectively colonizes the human gastric epithelium and is associated with stomach and colorectal cancer, as well as gastritis and peptic ulcer etiology. Genetic variability and its capacity to build biofilm are thought to be the reason why this bacterium is resistant to common antibiotics.|
As a result, several researchers have been looking out for natural products with possible antibacterial potential as an alternative, for example curcumin. Several studies have suggested that curcumin inhibits H. pylori infection via multiple roles.
To compare the antibacterial effects of five different formulations of curcumin.
Results and Discussion:
Overall, curcumin can reduce effects of H. pylori infection. However, activity varies between different curcumin samples, despite the clear activity of curcumin in general. Curcumin C3 Complex® (sample #1) was found to be the most active of all samples in all of tests conducted.