Turmeric extract (Curcumin C3 Complex®) is prepared from the dried rhizomes of turmeric (Curcuma longa) and contains a minimum of 95% curcuminoids. The name Curcumin C3 Complex has reference to its three main compounds – Curcumin, demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC).
Traditional knowledge with modern benefits
Turmeric is one of the oldest, most revered, and widely used medicinal plants in the world. It is infused in various health care systems and traditional practices with the aim to acquire overall wellbeing. Turmeric is extensively used in Ayurveda, the 5,000 year-old natural healing system of India, in managing several conditions, including those of the skin, pulmonary, and gastrointestinal systems, aches, pains, wounds, sprains, liver disorders, joint pain, and inflammation. All the health benefits of turmeric are attributed to curcuminoids, a constituent group of phytochemicals with characteristic yellow color (Betül Kocaadam and Nevin Şanlier, 2017).
Sabinsa’s turmeric is cultivated in controlled-contract farmlands with good agricultural practices. It is manufactured in FDA inspected, and USP-GMP and FSSC 22000:2005 certified facilities. The product is stringently tested to be free from pesticides, over one hundred of them. Every batch shall be analyzed for the naturalness through radiocarbon testing (https://www.nutritionaloutlook.com/herbs-botanicals/nutritional-outlooks-2016-best-industry-ingredient-supplierservice-provider-sabinsa-corp). Thus, it has enjoyed the confidence with customers over three decades in terms of quality and performance. While, in terms of dosage forms sold, Curcumin C3 Complex has sold in hundreds of millions of doses. It also has the TRU-ID certified certification (http://www.tru-id.net/certification/), Non-GMO Project Verified (https://sabinsa.com/nongmo) and received no objection letter from U.S FDA for Curcumin C3 Complex on its GRAS status. Honored with several merit awards such as Scientific Achievement Award by NBJ (2007), Product Merit Award by NBJ (2008), Functional Ingredients Editor’s Choice Award in the Marketing Category by Functional Ingredients (2012) and Winner of NutraIngredients-USA Award (2016). Sabinsa boasts that it provides the pharmacopeial standards of curcuminoids to US Pharmacopeia. The product has undergone thorough scientific scrutiny which is dictated by the fact that more than 150 research papers including 79 clinical studies have been published. All these making it an international award-winning ingredient as the most clinically studied Curcumin brand available today.
Golden spice – Golden metabolites
The “Yellow Curry Powder”, Turmeric, is one of the most valued spices dating back thousands of years for its food, medicinal, and even cosmetic uses. The most potent bioactive present in turmeric is curcumin, a pronutrient, i.e., it is converted into several active forms during metabolism when taken orally. Studies revealed that curcumin will get converted into phase I and Phase II metabolites within 3 hours after oral intake and it is the phase I metabolites (dihydro-, tetrahydro-, hexahydro- and octahydro-curcumin) that exhibit potent biological activity than the phase II metabolites (Vareed et al., 2008. Cancer Epidemiol Biomarkers Prev. 2008 June; 17(6):1411–1417). The curcuminoids have shown a multitude of pharmacological activities that are beneficial in improving human health and combat against various illness condition. They have been shown to maintain healthy blood glucose levels, normal lipid profile, support gut health, reduce oxidative stress, and resolve healthy inflammation responses.
Milestones – Curcumin C3 Complex®
1996: EP0839037 – Bioprotectant composition, method of use and extraction process of curcuminoids
1997: US 5861415 – Bioprotectant composition, method of use and extraction process of curcuminoids
2007: Sabinsa supported the United States Pharmacopeial (USP) Convention in preparing the monographs on curcuminoids and turmeric, and in developing in their validated analytical methods
2007: Scientific Achievement Award by NBJ
2008: Product Merit Award by NBJ
2009: Curcumin C3 Complex received self-affirmed GRAS status after a comprehensive review of safety and toxicology data by an independent panel of scientists of international reputed panel
2012: Functional Ingredients Editor’s Choice Award in the Marketing Category by Functional Ingredients
2013: Sabinsa has been issued a “No-comment” letter for Curcumin C3 Complex’s GRAS status from U.S. Food and Drug Administration
2015: Curry Powder to Clinical Significance, the 3rd book to be published on the scientific merits of Curcumin C3 Complex
2016: Winner of NutraIngredients-USA University Research of the Year Award
2020: Non-GMO Project Verified
Safety
The dietary intake of turmeric is considered safe since is one of the components of culinary preparations. Higher doses of curcuminoids are safe and easily tolerated by the human subjects even at a dose 12g per day in the cancer subjects. Also, product eminence is explicated by the fact that more than 21 nutraceutical/pharmaceutical companies are using Sabinsa’s Curcumin C3 complex, as one of the ingredients in their curcumin containing products.